It's been over a year since I deployed Django in production, and I wasn't looking forward to it. Last time, I had a lot of trouble with mod_python, sessions and decimal objects refuising to pickle.
Thankfully, all this really seems to have grown up in the last year - mod_wsgi is now the recommended way of deploying Django in production, and following the mod_wsgi django instructions, I was in business in 20 minutes. No fuss, no mess, no drama, and best of all, using daemon mode, no noticeable performance hit when serving static files and PHP off the same Apache installation. The ability to run the django project as its own unprivileged user when using daemon mode is also real handy.